Remeron is one brand name for mirtazapine, an antidepressant and alpha-2 antagonist. It is a tetracyclic antidepressant and is different from selective serotonin reuptake inhibitors (SSRIs) or tricyclic antidepressants (TCAs). This drug blocks specific alpha-2 receptors that subsequently increase norepinephrine and serotonin neurons in the brain. It also blocks a specific histamine receptor.
Why is this drug prescribed?
Remeron is FDA-labeled in adults for major depressive disorder. There is also some evidence that favors the usage for anxiety, dysthymia, obsessive-compulsive disorder, and panic disorder in adults.
Remeron is used to treat major depression. When taken to relieve depression, its effects are usually felt within one to four weeks. The usual adult dose is between 15 and 45 mg/day.
Remeron is being used experimentally to treat children with ADHD, autism, and Asperger Syndrome, but its effectiveness for these diagnoses is not clearly established.
At lower doses, Remeron has been associated with increased hypnotic effects and thus has been used for insomnia.
How much of this drug is typically used?
Tablet: 15 mg, 30 mg, 45 mg
Tablet, orally disintegrating: 15 mg, 30 mg, 45 mg
Reasons to buy Remeron:
Warnings and Precautions
There is no information on Remeron specific to children; all studies have been done with adults.
Rarely, Remeron causes flu-like symptoms such as a sore throat, chills or fever, mouth sores, or any other signs of infection which may indicate a serious blood problem. Such symptoms should be immediately brought to the attention of a doctor.
Remeron may cause drowsiness or difficulty thinking clearly. Patients should not drive or operate heavy machinery until it is known that Remeron does not seriously interfere with concentration and alertness.
For Pregnant or Nursing Mothers: Remeron has not been studied in pregnant women. Studies using very high doses in animals have caused fetal death. Remeron has not been shown to cause birth defects. It is not known whether Remeron passes into breast milk, and nursing mothers should be cautious.
Remeron should Not be used for people with the following conditions:
Remeron may be used with caution in people with the following conditions:
Remeron may cause the following reactions:
Interactions with Drugs and Other Substances
Drugs or substances that may interact with Remeron include:
Research Studies and Use in Child Psychiatry
Safety and efficacy of this drug have not been established in children and adolescents. A multi-center open label study did show benefit of mirtazipine in the treatment of adolescents with major depression 12-18 years old. The medication carries a special warning, as with other antidepressants, of increased suicidal thinking and behavior in children, adolescents and young adults.